A woman’s vaginal microflora is very sensitive, and the disruption of its delicate balance is a widespread source of discomfort that affects a large number of women at least once in their life. The most common types of vaginal infections experienced by women worldwide are bacterial vaginosis, mostly caused by Gardnerella vaginalis and fungal vaginitis, caused by Candida albicans overgrowth in 90% of cases.
Quatreflora™ is the brand name of Saccharomyces cerevisiae CNCM I-3856, an exclusive strain of beneficial yeast selected and patented for its unique capacity to be a safe, innovative solution of natural origin that has proven to help in both kinds of vaginal infections through several studies of which results have all been published in renowned peer-reviewed scientific papers.
A lot of the research covers the beneficial effects of Quatreflora™ for candida infections and the mechanism of action responsible for accelerating the clearance of C. albicans, which results from a coaggregation with the pathogen. However, the latest publication in Virulence journal specifically explores the antibacterial effect of the ingredient and its ability to fight Gardnerella vaginalis; thus, highlighting the full scope of its action. Finally a recent randomized Pilot Clinical Study proved the potential migration of the probiotic yeast Saccharomyces cerevisiae in the vaginal microbiota allowing it use in oral formulation.
- Highlight the importance of healthy vaginal flora.
- Show the potential use of S. cerevisiae-based probiotic for the management of bacterial vaginosis.
Speaker: Professor Luca Tiano
Dr. Luca Tiano, PhD Associate Professor in Biochemistry at the Department of Life and Environmental Sciences at the Polytechnic University of Marche. His main research activities presently concern the health effects of nutritional cofactor in healthy subjects and under pathological conditions associated with enhanced oxidative stress. Particular interest has been involved in research on bioavailability and biological effects of nutritional supplements and functional foods ingredients in cellular models or in vivo both under physiological and pathological conditions. Within this area of research was selected to conduct a European Community research project at the Marie Curie Training Site held by The University of Aberdeen, Scotland. Since 2002 he has been a researcher at the Department of Clinical Sciences at the Polytechnic University of Marche, Ancona, Italy. He is involved in joint research projects with Children’s Hospital, Salesi and the Heart Institute, Lancisi and since 2016 he is Associate Professor in Biochemistry at the Department of Life and Environmental Sciences at the Polytechnic University of Marche. Where he teaches Biochemistry, Nutrigenetics and a focus course on Oxidative stress in Biological systems. Supervised 4 PhD students and coordinates a research group composed of 5 post doc researchers. Among academic collaborations he has an active collaboration, funded with a three year grant by the Italian Ministry of Foreign Affairs with the South African Medical Research Council (Prof. C. Muller) and a collaboration with the, Université Pierre et Marie Curie, Paris 6 (. He is author of 103 papers on international peer reviewed journals (H factor 26, Cit 2500). He is on the board of the European Society of Comparative Biochemistry and Physiology and Executive Committee Member of the International Coenzyme Q10 Association.