Improved cellular efficiency has the ability to promote favorable outcomes for metabolic, infectious and autoimmune disease regardless of the etiology. Metabolic flexibility of the cell modulates interaction of cell metabolism and 2-way communication with the innate and adaptive immune system. Loss of metabolic flexibility leads to changes in thermodynamic ratios of nucleotide coenzyme couples NAD/NADH,NADP/NADPH,ADP/ATP and AcetylCoA/CoA in the nucleus, mitochondria, peroxisome, and cell cytoplasm disrupting cellular homeostasis. In this advanced course, we examine the differences between a healthy cell vs. inflamed cell, and the relevant pathways of returning to homeostasis.
- Review how cellular efficiency as the goal to treat autoimmune responses.
- Summarize the cellular changes in redox and altered mitochondrial functions that decreases the cell’s ability to maintain adequate antioxidant transcription.
- Discuss how Peptide therapies may reverse epigenetic changes and alter cellular phenotype for improved cellular function, and show promising efforts toward treating difficult autoimmune diseases.