For many years, mainstream textbooks typically characterized irritable bowel syndrome (IBS) as a psychosomatic disorder with a strong emotional component. Sophisticated molecular diagnostic techniques combined with genomic analysis have now shown that IBS is not a simple “functional” disorder. Rather, it is a multifactorial condition with several prominent overlapping subtypes, including dysbiotic, inflammatory, postinfectious, and neurochemical subtypes. This presentation will use the lens of system biology as way to tie together all these seemingly disparate elements into a cohesive diagnostic and treatment strategy when within scope and know when to refer when out of scope.
- Review conventional pathophysiological perspectives of IBS.
- Identify genetic variations and fecal microbial signatures associated with an increased risk of IBS.
- Discuss potential dietary and nutritional interventions for IBS based on a systems biology approach.