The incidence of autoimmune (AI) conditions is rapidly rising and viral agents have been implicated in the onset of many of these conditions. Epstein Barr Virus, (EBV), also known as human herpesvirus 4 (HHV4), is a member of the herpes virus family and is associated with infectious mononucleosis. EBV as well as other herpes class viruses such as HHV1, (herpes simplex), HHV3, (herpes zoster), HHV5, (cytomegalo), and HHV6 have all been associated with chronic immunologic challenge and especially with autoimmunity. The relation between these herpes class viruses and autoimmune diseases involves numerous mechanisms including molecular mimicry, epitope spreading and direct bystander activation. Autoimmune conditions directly associated with herpes class viral infection include Hashimoto’s thyroiditis, Type-1 diabetes, Multiple Sclerosis, Scleroderma, Sjögren’s, Rheumatoid Arthritis and others. The association between the herpes class viruses and AI will be described in this lecture, with particular focus on EBV. Based on the most recent research studies we will discuss the nature of herpes virus infection, its pathophysiology, as well as the prevalence. An algorithm for diagnostics will be described and useful insights into clinical application and therapeutics. A case study may be discussed.
- Participants will be able to describe the herpes virus infection: with emphasis on EBV, CMV and HHV-6.
- Participants will be able to discuss various modes of viral influence on immune reaction.
- Participants will be able to define the mechanisms by which herpes virus are associated or cause autoimmunity.
- Participants will be able to describe laboratory testing and interpretation of herpes virus with emphasis on EBV, CMV and HHV-6.
- Participants will be able to discuss therapeutic interventions useful in clinical environment.