The fascial system is a three-dimensional continuum of soft, collagen-containing, loose and dense fibrous connective tissue that permeates the body and enables all body systems to operate in an integrated manner. Fascia is the morphological/ histological “sheet or any other dissect-able aggregations of connective tissue that forms beneath the skin to attach, enclose, and separate muscles or other internal organs”. The fascial system is susceptible to the dramatic changes in a woman’s body during the perimenopausal transition.
With fluctuating estrogen, progesterone and testosterone in the perimenopausal transition, it is not surprising that a perimenopausal woman often complains of joint aches and pain. With appropriate hormone replacement, joint ache and pain often dissipate. The opposite is true, with the increased rise of breast cancer and usage of aromatase inhibitors to inhibit estrogen, it is not surprising that a common side effect of third generation aromatase inhibitors (AIs) such as letrazone have a 21 to 25% reported rate of arthralgias.
It is also known that progesterone rises 300 times baseline during pregnancy (pro-gestare is Latin and means “for pregnancy”). Progesterone relaxes connective tissue in order to accommodate an ever-expanding fetus in the pelvis. It is clear that the hormone receptors on the fascia play an important role in structural integrity and pain transmission. Optimal management of hormones in the perimenopausal transition can greatly increase quality of life and structural integrity.
- Participants will be able to discuss the Fascial System and its importance in integrative medicine, specifically that of transmitting peripheral nerve and pain signals.
- Participants will be able to discuss hormonal effects on the Fascia and its importance in the perimenopausal transition.
- Participants will be able to discuss BPC-157, a peptide that can be used to support collagen formation and treat intestinal hyperpermeability.