DNA methylation is a well-researched, primary epigenetic process that has been used to establish biological age assessments, namely DNA methylation “clocks,” which act as surrogate markers of age-related morbidity and mortality risk. The potential for reversing biological aging using these clocks is just beginning to be explored. Yet emerging research suggests that it is possible to do just that. Expansion of healthspan (with lifespan) has profound implications for the growing health-related economic and social challenges of our rapidly aging population. A 2021 publication in Nature Aging proposes that a slowdown in aging that increases life expectancy by a single year is worth US $38 trillion dollars, and by ten years, US $367 trillion dollars.
- Review the current landscape of research on DNA methylation, with a focus on DNA methylation biological age.
- Observe how dietary and lifestyle inputs affect DNA methylation and biological aging and be able to apply those in clinical situations.
- Indicate how to fine-tune methylation support to take into consideration the potential for negative outcomes from long-term, high-dose methyl donor supplementation.