The clinicians’ task is not to simply extend life, but to decrease or prevent disability or prolonged morbidity. That task has been made easier by recent advances in genomics research and cellular biology. By understanding the underlying molecular events and disrupted signaling pathways thought to be responsible for senescence, disease, and aging, we can determine the most effective strategies to maintain optimal performance and zestful health. This presentation will explore the various factors that can activate or downregulate the primary intracellular biochemical pathways associated with aging and longevity, including AMPK/sirtuins, mTOR, and Nrf2/ARE. We will then review the literature regarding lifestyle practices and dietary supplements that can potentially modulate those pathways in beneficial ways.
- Participants will be able to discuss the pervasive pathological processes involved in senescence and how these processes can lead to aged-related disease.
- Participants will be able to utilize practical applications of current research on exercise, caloric restriction, and time-restricted feeding to demonstrate the potential role of specific genome-based diets in slowing down the aging process.
- Participants will be able to discuss research on different classes of dietary supplements used to ameliorate the aging process, including antioxidants, sirtuin inhibitors, Nrf2 activators and telomerase modulators.