Autoimmune diseases are conditions in which the immune system damages normal components of the individual. Thus autoantibodies productions were found to be multifactorial in their etiology. For practical reasons these factors are classified into four categories:
Genetic, which entail the MHC class I, II, and III. A case in point will be the haplotypes of HLA-DRB1 which are prevalent in many classical diseases.
Immune deficiencies: C1q C2, C4 and IgA deficiencies are among the most common defects associated with diverse autoimmune conditions.
Hormonal state, most autoimmune diseases are detected in females at the child bearing ages. The role of estrogens will be delineated. In addition other hormones play a role i.e. prolactin.
Emergence environmental causes: Those are the most important as a trigger factors (i.e. adjuvants) determining the time and type of disease. They entail infectious agents, chemicals, drugs and even vaccines.
The type of disease in an individual, in an autoimmune prone family, will be determined by the specific combination of the different factors mentioned above.
A special emphasis will be put on smoking, on unsaturated fats, salty diet, chocolate, coffee, spicy food, cannabinoids, and the interaction with component of parasites.
- Participants will be able to discuss why autoimmune diseases are determined by genetics.
- Participants will be able to discuss how the induction of autoimmune diseases is multi-factorial (the mosaic).
- Participants will be able to discuss how autoimmune diseases can be controlled by a proper diet.