This evening symposia will provide an overview of our current understanding of the endothelial glycocalyx structure and function across the microvasculature and its systems biology implications. We will also discuss disease or injury states, such as infection, sepsis and trauma, where endothelial glycocalyx dysfunction contributes to severe inflammatory vasculopathy and how to use targeted nutrient therapies to regenerate a strong endothelial glycocalyx for improved wellbeing and longevity.