Over the last decade, fecal microbiota transplantation (FMT) has established remarkable clinical efficacy in the management of recurrent and/or refractory Clostridioides difficile infection. Technological advances in gut microbiota and metabolomic analysis have permitted new studies on the effects of gut microbiota and dysbiosis on human health. In this lecture, the history of fecal microbiota transplantation and its evolution to investigate its potential therapeutic role in luminal illness of the gut and in non-intestinal ('beyond the lumen'). Latest research initiatives and research will be shared in this exciting new field of investigation.
Learning Objectives:
- Summarize the historical evolution of FMT and the clinical evidence for its role in recurrent and/or refractory C. difficile
- Review literature on evolving research in non C difficile infection disease states (eg, Crohn's, Ulcerative colitis, Immune checkpoint inhibitor colitis)
- Discover evolving research into non-intestinal disease therapy (eg, non-alcoholic fatty liver disease, hepatic encephalopathy, autism, recurrent UTI, multi-drug resistant organism eradication)
