February 20-22, 2025  •  Hilton Midtown  •  New York, NY

Session Details

The Original Magic Bullet: Methylene Blue. History, Mechanisms, Dosing, and Clinical Applications

Feb 15 2024

1:30 PM - 2:30 PM EDT

Gibson Suite

In the last few years, the use of methylene blue in clinical practice has risen dramatically. Patients with chronic inflammation, autoimmunity, acute infection, post infectious symptoms (including Long Covid), acute trauma, neurocognitive conditions, and so much more are seeing profound benefits from a very (very) old compound.

Way back in 1897, methylene blue was the first drug registered with the FDA. Initially used for the treatment of malaria and as a potent antimicrobial, methylene blue was the first drug to be coined as “magic bullet” because of its myriad mechanisms of action and clinical applications.

In this lecture, we will discuss the history of methylene blue and dive deep into the mechanisms of action, especially how it enhances mitochondrial function (in least 8 different ways, including bypassing the first two complexes on the electron transport chain).

We will also discuss the nuances of dosing, it’s powerful mood boosting properties as an MAO-I inhibitor, its resurgent use in chronic infections, how to combine methylene blue with red light, how to leverage it for performance gains (increasing aerobic threshold) and precautions to take into consideration, including the purity problem, and much more.

Learning Objectives:

  1. Investigate the history of Methylene Blue.
  2. Examine Methylene Blue’s Mechanisms of Action.
  3. Examine Methylene Blue dosing and indications.


Smarter Not Harder

- Chief Operating Officer of Health Optimization Medicine and Practice

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