Over the past decade it has become more well recognized that the common health issues that now plague us are related to alterations in the connection among the immune and nervous system and metabolism at the organ specific level. In essence, the root cause of most chronic illnesses is related to the interaction between the immune system and cellular metabolism. Alterations in blood sugar and insulin sensitivity, chronic low-grade inflammation, oxidative stress, and alterations in brain microglial cell activity all associate as root cause origin of disorders as broad as type 2 diabetes, obesity, pre-autoimmune diseases, cognitive impairment, mood disorders, fatigue-related disorders including Long Covid, and compromised endurance and muscle loss (i.e. Sarcopenia). This presentation will review the advancing understanding of the clinical importance of alterations in immuno-metabolism and approaches focused on remediation of clinical issues associated with restoring immune system resilience. 

Session Learning Objectives:

1.) Understand the Intersection of Immunology and Metabolism

• Describe the key metabolic pathways (e.g., glycolysis, oxidative phosphorylation) and their roles in immune cell function.
• Explain how metabolic changes influence the activation, differentiation, and function of immune cells in health and disease.

2.) Analyze the Role of Immuno-Metabolism in Chronic Diseases

• Evaluate the contribution of immune-metabolic dysregulation to the pathogenesis of chronic diseases such as diabetes, cardiovascular disease, and autoimmune disorders. 
• Identify how inflammation-driven metabolic changes exacerbate chronic disease progression.

3.) Explore Therapeutic Strategies Targeting Immuno-Metabolism

• Discuss current and emerging therapies that target immune-metabolic pathways to treat chronic diseases.
• Critically assess the challenges and opportunities of modulating immuno-metabolic pathways in clinical settings.